VACCINE-THERAPY 135 



a similar manner, and obtained a serum which he found 

 very efficacious. He ascertained, if he injected 2 c.c. of 

 this serum into a rabbit along with 1 c.c. of a fresh virulent 

 broth culture of the bacillus, the animal did not die. In 

 man he injected 30 to 40 c.c. into the flank in several 

 places, and noted a rise in temperature, followed by 

 recovery. He considers the serum is antibacterial, and 

 stimulates the leucocytes. 



3. Legge treated sixty-seven cases (British Medical 

 Journal, 1905) with this serum, and in fifty-six the serum 

 was used alone. He considers the exact mode of action of 

 the serum is unsolved. 



4. Deutsch has also prepared a serum which appears to 

 be effective in cattle. It agglutinates the bacilli, and con- 

 tains an immune body capable of destroying the organisms 

 in the presence of a suitable complement. 



5. Sobernhein has made an antiserum which he com- 

 bines with a vaccine similar to Pasteur's No. 2, and used 

 the two at the same time with excellent results. 



This method appears to be less dangerous than Pasteur's, 

 and, more virulent doses being given, a greater degree of 

 immunity is arrived at. 



To be efficacious, it would appear, very large doses of the 

 serum must be given. 



