150 CLINICAL BACTERIOLOGY AND 



taken place, and the consequences are then generally 

 disastrous. 



In those cases where pronounced local abscess forma- 

 tions are the order of things, it is imperative the pus 

 cavities should be evacuated as soon as possible. By 

 so doing internal pressure is relieved from the abscess 

 wall, thereby allowing the bactericidal elements, by a 

 process of osmosis, to reach the infective centres. It also 

 tends to prevent the risk of metastatic invasions, a condition 

 always to be feared and warded against in strangles. 



We usually begin by giving an autogenous vaccine 

 of streptococci, composed of 250,000,000 as a dose, and if 

 the case is sufficiently bad we add 20 c.c. of antistrepto- 

 coccic serum. 



The serum we repeat the next day (30 c.c), noting the 

 temperature, pulse, etc. On the third day, if necessary, 

 we give 40 c.c, and if the case is progressing we leave off 

 doing anything further until the fifth day, when we repeat 

 the vaccine, giving 500,000,000. If the negative phase is 

 pronounced, it is better to wait and note progress for 

 three to five days before giving another 500,000,000 to 

 1,000,000,000 for a dose. If the negative phase is only 

 indifferent, do not wait so long, but within twenty-four 

 hours give 500,000,000 to 750,000,000, and watch the 

 result. In obstinate cases one may have to follow up 

 treatment for a considerable period, increasing the doses 

 as one goes along, and watching the phenomena. 



The dose of serum, and the number of times it should be 

 administered, must be items left largely to the individual 

 immunizer upon which to exercise his judgment. 



Purpura Hemorrhagica. 



It is probable this disease in equines is never seen as 

 a primary condition, but is met with in practice as secon- 

 dary to such specific debilitating disorders as influenza, 

 strangles, etc. 



That the phenomena produced are due either to a direct 



