VACCINE-THERAPY 155 



It may be taken for granted, if one horse in a stud or 

 stable is suffering from influenza, others are sure to follow, 

 and that, in fact, they are invariably already incubating the 

 disease. 



Should the outbreak be a severe one, with a tendency to 

 the development of sequela?, every animal should have, as 

 a prophylactic, an injection of a mixed vaccine, preferably 

 derived from the cultivated bacteria obtained from the 

 first animal to succumb to the disease. 



Of course, it does not follow every animal will show the 

 same variety of bacteria, even in the same stable ; but it may 

 be taken for granted that a vaccine derived from a patient 

 suffering from the disease similar to the infection to which 

 the others have been subjected, and under the same roof, is 

 more likely to contain the identical or analogous bacteria 

 than if procured from a patient exotic to the diseased area 

 or building. 



If streptococci are present, it is an advantage to combine 

 antistreptococcal serum with the vaccine. 



When an animal is suffering severely, and sequelae set 

 in, an autogenous vaccine should be made from the dis- 

 charges, and the animal treated according to its condition. 



In the few cases in which we have taken the opsonic 

 index in influenza sequela?, it has invariably been very 

 low to streptococci, and in one case it was only 039. 



Three days after injection another estimate of the 

 opsonic content was made, and it was found to have risen 

 to 1-57. 



So far as influenza and strangles are concerned, we have 

 already seen, grave sequela? may follow either, and in 

 many cases with fatal results. There is a condition, how- 

 ever, where there is no tendency for such fatal terminations, 

 and yet the utility of the animal is greatly handicapped for 

 life, and the monetary losses to the owner are serious. 

 We all know how liable hunter stock are to become roarers 

 and whistlers, particularly if they should suffer from 

 influenza or strangles, and even severe colds. 



