168 CLINICAL BACTERIOLOGY AND 



valent antistreptococcal serum (bovine), in the following 

 combinations : 



Streptococci ... ... ... 250,000,000 



Staphylococci ... ... ... 500,000,000 



Tuberculin ... ... ... 2 c.c. 



Antistreptococcal serum (bovine) ... 20 c.c. 



To be repeated in three to five days. 



The patient's temperature invariably falls, the appetite 

 improves, and the respiration becomes slower and deeper; the 

 coat regains its lustre, the condition generally improves, and 

 the animal puts on flesh. When the disease runs a very 

 rapid course, and the immunizer is called in too late, auto- 

 intoxication may be so far advanced that no recovery can 

 be looked for or expected. 



We have been greatly struck with the rapid manner the 

 above vaccine has cleared up the bronchial discharges. 

 The cases which run a latent course are clearly those 

 where secondary invasion has either never taken place, 

 or, if it has, Nature's antibodies have succeeded in resisting 

 the attack to a large extent. We strongly believe that every 

 animal has the power of resisting the bacillus of tubercle, 

 some to a greater degree than others. (See Appendix II.) 

 An illustration of this is seen in the way Nature isolates and 

 throws out an artificial wall round the foci of tubercle so 

 imprisoned, killing them off, the focus often ending in a 

 caseating or calcifying degenerate mass, and all that 

 remains to show what has taken place may only be a 

 cicatrix. Should the bacilli, however, extensively invade 

 the lungs, these foci interfere with the circulation and 

 respiration, and a general toxasmia with extreme depression 

 follows, giving an excellent opportunity for other bacteria 

 to gain a footing. They in turn multiply rapidly, the patient 

 in the end dying from acute toxasmia largely due to a 

 secondary invasion. When an animal is very extensively 

 diseased with advanced tuberculosis, we know tuberculin 



