APPENDIX. 285 



necessary if the NaOH solution had been N/io. It is therefore necessary to dilute 

 the sodium-hydrate solution in the proportion of 10 to 10.5. Measure exactly 1000 

 c.c. of the too concentrated sodium-hydrate solution and add to it 50 c.c. of distilled 

 water, mix thoroughly, and we have 1050 c.c. of N/io solution of NaOH. 1000 x 

 10.5 = 10.500. 10.500-7-10=1.050. 



As Acidum hydrochloricum U. S. P. is about two-thirds water (68.1%) to make 

 N/io HC1, which would require 3.65 in 1600 c.c., it would be necessary to take about 

 three times this amount of U. S. P. acid. Take 12 c.c. of the acid and add distilled 

 water to make 1 100 c.c. Put 10 c.c. of this dilute solution in a beaker. Add phenol- 

 phthalein solution and titrate. If n c.c. of N/io NaOH were required it would be 

 necessary to add 100 c.c. of water to a volume of 1000 c.c. of the diluted hydrochloric 

 acid. looo x n = nooo-f- 10 = noo. 



Other acid and alkali solutions can be made as for N/io HC1 and N/io NaOH. 



D DISEASES OF UNKNOWN OR NOT DEFINITELY DETERMINED 



ETIOLOGY. 



OF TEMPERATE CLIMATES. 



Acute Articular Rheumatism. Various bacteria have been reported as cause. 



Foot-and-mouth Disease. Probably due to an ultramicroscopic organism. 



Measles. Cause entirely unknown. Hektoen has shown that blood contains 

 .the virus. 



Mumps. Herb has implicated a diplococcus. Inoculations into Steno's duct 

 of monkey successful. 



Rabies. Probably the Negri bodies. 



Roetheln (German Measles). Nothing known. 



Scarlet Fever. Streptococci seem most probable cause (S. anginosus). 

 Mallory has implicated epithelial protozoa. 



Small-p3X and Vaccinia. Guarnieri and Councilman have implicated epithe- 

 lial protozoa. 



Spotted Fever of the Rocky Mountains. Supposed to be due to an unknown 

 protozoon transmitted by a tick. 



Typhus Fever. It has been suggested that the cause may be a protozoon trans- 

 mitted by vermin. 



Varicella. Entirely unknown. 



Whooping Cough. Influenza-like bacilli have been implicated. 

 OF TROPICAL CLIMATES. 



Ainhum. (A disease characterized by a constricting fibrous ring, especially 

 of little toe, often leading to spontaneous amputation.) 



Beriberi. Various microorganisms and food factors suggested. 



Blackwater Fever. Considered as a malarial disease, but thought by some 

 to be possibly caused by a protozoon a Babesia (Piroplasma) 



Dengue. Supposed to be due to a protozoon transmitted by Culex fatigans 



