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and the fleece drops out in patches. There is an uncer- 

 tainty and incoordination of the muscular movements, 

 comparable to that exhibited in cases of drunkenness. 

 The animal wanders aimlessly about, straying from the 

 flock. Sight and hearing are affected. In some cases com- 

 plete blindness ensues, and in others the animal is unable 

 to judge the size of objects, or its distance from 

 them. In later stages fits of trembling follow each other 

 at short intervals and the power of locomotion is gradu- 

 ally lost. Death comes from exhaustion and lack of nutri- 

 tion. 



Cattle and horses sometimes become dangerous. Cattle 

 have been known to attack persons or other animals. 

 Locoed horses may work as usual for some time and then 

 develop vicious fits of kicking. Their lack of judgment 

 of the distance and size of objects is often very marked. 

 They become easily frightened at imaginary objects and 

 run away. As is the case with sheep, they become 

 stupid and lethargic as the disease progresses. Chesnut 

 and Wilcox tell of one horse that spent two weeks with- 

 out moving from a spot of dry ground one hundred and 

 fifty feet square. The horse then walked some distance 

 to a stream and in attempting to drink, fell and was un- 

 able to rise. 



When a large quantity of the weed is eaten by an ani- 

 mal unused to it, acute poisoning results- The symptoms 

 Acute are mucn m ore violent than in chronic cases. 

 Locoism I R a case described by Chesnut and Wilcox the 

 animal, a sheep, was completely blind within 

 ten hours after she was first observed eating Loco Weed. 

 She exhibited locomotor ataxia, walking in circles with 

 her head bent to the right. As the disease progressed the 

 circles became smaller. Pronounced muscular twitchings 



