AKTIZYMOTICS, AiN^TIPYRETICS, ANTIPERIODICS. 161 



ing. This may be avoided by giving the drug in 

 aerated water. It is rapidly absorbed and but slowly 

 eliminated, which last process is carried on chiefly by 

 the kidneys. It does not lower the body tempera- 

 ture in health, but has great power to do so in ab- 

 normal body temperature, whether given internally, 

 subcutaneously, or intratracheally. Its effects as a 

 febrifuge are due to diminished heat-production. 

 Occasionally it will produce a profuse perspiration, 

 vertigo, collapse, and in the dog at times a rash re- 

 sembling that of measles. Antipyrine may be given 

 in all febrile and inflammatory diseases, influenza, 

 acute muscular and articular rheumatism, and dia- 

 betes insipidus, in doses for the horse of 3 i.-iv. ; for 

 the dog, gr. v.-xx. Externally— it is employed in 

 five- to ten-per-cent. solutions as a haemostatic; sub- 

 cutaneous injections of the drug are used to relieve 

 pain and nervous irritability in the treatment of colic 

 (dose about one-third of that per os). 



ACETANILIDUM — ACETANILID. 



(Known also as Phenyl Acetamide, Antifebrin [a 



trade name].) 



Acetanilid is obtained by the reaction of glacial 

 acetic acid on anilin. It occurs as colorless or whit- 

 ish, shining, odorless crystals, having a slightly 

 burning taste and a neutral reaction. Soluble in 190 

 parts of cold water, in 18 parts of boiling water, and 

 in ^ parts of alcohol ; also soluble in chloroform and 



ether. Dose: H., 3i.-ij.; D., gr. v.-xv. 

 11 



