KI.KCTKICAI.LY STIM Ul.ATKl) (:\N(;l,|i>N dOI.I.S. 2.'{ 



2. Change from a smooth and rouiulcd to a ja<(j^c(l, 

 irregular outline. ."3. Loss of open reticular ai>pear- 

 ance with darker stain. 



B. For the cell protoplasm : I. Slight shrinkage in 

 size. 2. Lessened power to stain or to reduce osmic 

 acid. .'5. Vacuolation. 



('. For the cell capsule : Decrease in size of the 

 nuclei. 



Incidental Observations. 



A niunher of suggestive observations, made; in the 

 course of the investigation and not belonging properly 

 to the body of the paper, may be mentioned here. 



A strange differentiation of some sort between the 

 large and small cells of the spinal ganglia is brought 

 to light by stimulation. The large cells show the 

 effects of work ; the small cells, very little or not at 

 all. The fact is too marked to pass by unnoticed. 

 Considering all the cells large which have one diame- 

 ter 50 ft or over, and those small which have not, a 

 count gives the following result : 



Cat No. 11. First Thoracic Gaufjlia. 



In 100 larjre cells nuclei : In 100 small colls nuclei : 



Shrunken. Not shrunken. Shrunken. Not shrunken. 



Resting, 5 95 ' 100 



Stimulated, 94 6 S 92 



A few fibers going to a ganglion of course escape 

 stimulation by our method. This accounts very well 

 for the few large cells which do not appear worked in 

 the stimulated ganglion. It cannot account for this 

 condition in the multitude of small cells which com- 

 prise over half the cells in a ganglion. No explana- 

 tion will be attempted until further experiment is 

 made. As might be expected, a few cells in the resting 

 ganglion appear worked. 



In close relation to our work is the (piestion of the 



