468 INHERITANCE. Chap. XII. 



" 1st. Appearance of epilepsy in animals born of parents ha\'ing 

 been rendered epileptic by an injury to the spinal cord. 



" 2nd. Appearance of epilepsy also in animals born of parents 

 having been rendered epileptic by the section of the sciatic nerve. 



" 3rd. A change in the shape of the ear in animals born of parents 

 in which such a change was the effect of a division of the cervical 

 sympathetic nerve. 



" ith. Partial closure of the eyelids in animals born of parents in 

 which that state of the eyelids had been caused either by tlie 

 section of the cervical sympathetic nerve or the removal of the 

 superior cervical ganglion. 



" 5th. Exophthalmia in animals born of parents in which an injury 

 to the restiform body had produced that protrusion of the eyeball. 

 This interesting fact I have witnessed a good many times, and I 

 have seen the transmission of the morbid state of the eye continue 

 through four generations. In these animals, modified by heredity., 

 the two eyes generally protruded, although in the parents usually 

 only one showed exophthalmia, the lesion having been made in most 

 cases only on one of the corpora restiformia. 



" 6th. Hoematoma and dry gangrene of the ears in animals born of 

 parents in which these ear-alterations had been caused by an injury 

 to the restiform body near the nib of the calamus. 



" 7th. Absence of two toes out of the three of the hind leg, and 

 sometimes of the three, in animals whose parents had eaten up their 

 hind- leg toes which had become anjEsthetic from a section of the 

 sciatic nerve alone, or of that nerve and also of the crural. Some- 

 times, instead of complete absence of the toes, only a part of one or 

 two or three was missing in the young, although in the parent not 

 only the toes but the whole foot was absent (partly eaten off, partly 

 destroyed by inflammation, ulceration, or gangrene). 



" 8th. Appearance of various morbid states of the skin and hair of 

 the neck and face in animals born of parents having had similar 

 alterations in the same parts, as effects of an injury to the sciatic 

 nerve." 



It should be especially observed that Brown-Sequard has 

 bred during thirty years many thousand guinea-pigs from 

 animals which had not been operated upon, and not one of 

 these manifested the epileptic tendency. Nor has he ever 

 seen a guinea-pig born vi^ithout toes, which was not the 

 oifspriug of parents which had gnawed off their own toes 

 owing to the sciatic nerve having been divided. Of this 

 latter fact thirteen instances were carefully recorded, and a 

 greater number were seen; yet Brown- Seqnard speaks of 

 such cases as one of the rarer forms of inheritance. It is a 

 still more interesting fact— 



