374 CANINE MALARIA 



of death the free parasites were still more numerous. He 

 found little evidence of phagocytosis in the cases examined. 

 Nucleated red corpuscles appeared in films from three dogs 

 the day before death, and in three other dogs they appeared 

 six days before death. Blood pigment was present in nearh' 

 all samples of urine. 



The period of incubation 2ii\.Q.x direct inoculation is about 

 three days. 



§ 292. Symptoms. Two distinct forms have been 

 described : the acute which is nearly always fatal, and the 

 chronic which often terminates in recovery. In the acute 

 form the dog is dull, drowsy and refuses food. It may be 

 thirsty. The temperature is high (i04°F.) but after two or 

 three days it drops to subnormal. Icterus is not constant and 

 the hemoglobinuria is not always present. The blood is pale 

 and it coagulates slowly. The red corpuscles are reduced to 

 2,000,000 per cubic millimeter or below. The polynuclear 

 leucocytes are increased in number. Death nearly always 

 occurs in from three to six days. 



In the chronic cases the fever remains high for from 36 to 

 48 hours, when it returns to normal. The anemia is the most 

 constant symptom. The mucosae become pale and the appetite 

 is poor. The symptoms persist for from three to six weeks. 

 Recovery is the rule. 



§ 293. Morbid anatomy. The mucous membranes are 

 pale and the subcutaneous tissue and fat more yellow than 

 normal. The spleen is 3 or 4 times the normal size. The 

 liver is engorged with blood which is heavily charged with 

 parasites. The gall bladder is distended with greenish bile. 

 The mucosae of the digestive tract are slightly, if at all, 

 changed. The kidneys are congested, often sprinkled with 

 petechiae or ecchymoses. The capsule is easily removed. 

 The parasites are found in the blood in the early stages of the 

 disease. They are more numerous in the capillaries than in 

 the heart blood. 



The lungs are in some cases edematous. In all young 



