48o 



RABIES 



rabies the inoculation wound in the head should be healed 

 perfectly, there should be no abscess and the menings should 

 be free from exudates and the brain should appear perfectly 



normal, except that in rare cases 

 there may be a slight injection 

 of the blood vessels. The viscera 

 are ordinarily normal in appear- 

 ance, with possibly the exception 

 /' ' f)-/'^'f^Y^'^^^"'~\ of the liver, which we have 

 "^'^ ' ^ ^' ' ^ frequently found to be deeph^ 



reddened and the gastric mucosa, 

 which not infrequently shows 

 dark patches, indications of dis- 

 integrated hemorrhagic areas. A 



c- 





^ 



^£^.^' 



Fig. III. Section of a normal 

 plexiformga7iglion ; {a) and 

 {b) ganglion cells, {c) in tercel 

 hilar substance. 



b—.L 







? 





bacteriological examination fails 

 to reveal the presence of micro- 

 organisms in either the tissues 

 or blood. Another important 

 point which has been noticed 

 is an intense rigor mortis fol- 

 lowing death from rabies. Kin- 

 youn states that this was a 

 . ^ , -s constant feature of this disease 



(wl ^ tV'^ ^""^ *^.'^i^;l in all of the produced cases 



'4^«- 7*/)»'J ■.-• ^fl which have come under his ob- 



servation. Wesbrook did not 

 observe this condition. 



Animals other than rabbits 

 have been used and a number of 

 of other methods of inoculation 

 have been proposed. 



Diagnosis by histological ex- 

 amination of the gatiglia. The rapid diagnosis by means 

 of the histological changes pointed out by VanGehuchten 

 and Nelis has been very successful in the experience of 

 a number of workers. Ravenel was the first to publish 

 upon this method in this country. He used it very 





Fig. 112. Section of ple.vi- 

 form ganglion from a case of 

 rabies ; {a) ganglion cell, {b) 

 cells infiltrating the ganglion 

 cell and space. 



