SYMPTOMS 507 



streptococcus has often appeared in pure cultures from the 

 various organs. Carre has shown that the serous discharge 

 obtained at the outset of the disease possesses great pathological 

 power, and that its virulence was due to the presence of an 

 organism sufficiently small to pass through certain filters. 

 There is much need for further investigation into the etiology 

 of this malady. That it is produced by a specific cause is very 

 clearly indicated by the reported results of investigations to 

 the effect that dogs inoculated with the nasal discharge of 

 affected animals develop the disease. 



S 395- Symptoms. The symptoms appear after a period 

 of incubation of from four to six, possibly eight days. They 

 vary to such a degree that it is impossible to refer to all of the 

 manifestations. In some cases the symptoms suggest a gen- 

 eral disorder. In others they are referable to certain parts or 

 organs such as the mucosa of the digestive and respiratory 

 tracts, the brain or integument. As a rule several organs are 

 implicated. 



The initial symptoms such as depression, roughened con- 

 dition of the coat, loss of appetite and elevation of temperature 

 are suggestive of a general disturbance. 



In a large majority of cases, conjunctivitis is the primary 

 ocular symptom. Tears flow from the eyes and photophobia 

 is present. The mucous membrane of the eyelids becomes 

 conjested and a purulent exudate may appear. The exuded 

 matter consists of pasty mucous or dirty yellowish pus. This 

 exudate collects under the lower eyelids, chiefly at the inner 

 canthus of the eye and soils the edges of the eyelids, upon 

 which it frequently dries and causes the lids to adhere, espec- 

 ially during the night. Ulcers form on the cornea in conse- 

 quence of the action of the accumulated and decomposing pus 

 and the patient wiping and rubbing the eyes with its paws. 

 The epithelium of the cornea sometimes suffers more or less 

 from shallow flat lesions which give the surface of the cornea a 

 rough and uneven appearance. Frequently smaller and deeper 

 ulcers form especially toward the center of the cornea. 



