274 APPENDIX A 



phenomena that to begin with there should be a local 

 breakdown of balance at the point of irritation, and 

 the spread of it into normal epithelium which does 

 not immediately revolt is no more surprising than that 

 a social riot, in which the police have been over- 

 powered, should spread, and yet be repelled for a time 

 in areas where they are still strong, and the inhabitants 

 have not been excited to disorder. It is no vain 

 metaphor to suggest that in the body politic the police 

 greatly resemble the wandering connective-tissue cells 

 of any organism. 



In conclusion, it may be repeated, and even in- 

 sisted on, that only the developmental and endocrine 

 theory shows any reason whatsoever for the basal facts 

 of malignancy, that is, for the actual undue prolifer- 

 tion of tissue cells, their tendency to revert to an em- 

 bryonic character, and their power to spread beyond 

 normal boundaries, while the biological conception of the 

 organism as a federation of cell-colonies working in a 

 harmony, which is the result of " constraining bodies," 

 throws a brilliant light on invasiveness as the result of 

 a failure in such inhibitions. 



REFERENCES 



Emery D'Este. — " Tumours," 1916. 



Shattock and Dudgeon. — "Feeding Experiments with Mouse- 

 cancer," Proc. Royal Soc. Med., voL x. p. 35, 1916-17. 



