148 Inheritance of Specific Iso-agglutinins in Human Blood 



Conclusion. 



From the foregoing considerations it is permissible to deduce that 

 the iso-agglutinins present in human blood are inherited, and that as a 

 general rule the inheritance follows Mendelian laws. There arises however 

 a modifying factor, in the observation by Bond, that iso-agglutinins 

 formerly absent in the serum of a given person may appear in that 

 serum after the person has successfully withstood a systemic infection. 

 It would be interesting in such cases to know the groups to which the 

 parents of the person belonged. 



The writer gladly takes this opportunity of recording his indebtedness 

 to Prof. D, Noel Paton, in whose laboratory the work was carried out, 

 for assistance in its inception, and help in its execution ; to the Medical 

 Research Committee for the monetary grant which made the work 

 possible ; to Dr J. W. McNee, D.S.O., Prof. W. Bulloch, Col. C. J. Bond, 

 C.M.G., for supplying references and hints on technique ; to Mr J. M. 

 Graham, F.R.C.S.E., for the original supply of test sera; and to Prof. 

 Punnett, who has kindly revised the section " Analysis of Families." 



REFERENCES. 



Bond, C. J. Brit. Med. Journ. December 8, 1917. 



Brit. Med. Journ. March 2, 1918. 



HiRSCHFELD, L. and Hirschfeld, H. Lancet, October 18, 1919. 

 Landsteiner, W. Wieii. Klin. Woch. No. 14, p. 1132, 1901. 

 Moss, W. L. Bull. Johns Hopkins Hosp. p. 63, March, 1910. 



Journ. Amer. Med. Ass. June 23, 1917. 



Robertson, O. H. Memorandum on Blood Transfusion, M.R.C. Sept. 1918. 



VoN DuNQERN and Hirschfeld, L. Zeit.f. Immunitatsforsch. No. 8, p. 526, 1911. 



