ON SPECIFIC THERAPEUTICS. 65 



tumour. In rapidly growing sarcomata and 

 carcinomata the second inoculation almost 

 always had a negative result ; at best, the 

 second tumour remained far inferior in size to 

 the primary one. Only in the very slowly 

 growing chondromata was there no distinct 

 difference in their energy of proliferation. 

 These results agree with the following obser- 

 vation, which has been confirmed thousands of 

 times. If, as is regularly done in my Institute, 

 the inoculation is carried out by introducing 

 the capillary tube at the groin and pushing it 

 up as far as the axilla, the greater quantity of 

 inoculated material will of course be deposited 

 at the latter site, whilst only a small portion 

 will remain at the groin. In the case of the 

 rapidly growing carcinomata and sarcomata the 

 large principal tumours almost always develop 

 in the axilla, whilst a minute nodule is usually 

 found in the groin. In the case of the chon- 

 dromata, however, both tumours usually show a 

 fairly equal development. Thus, in the latter 

 case, the macroscopical appearance somewhat 

 resembles that of an hour-glass, whilst in the 

 former it is more like a balloon with its car 

 attached. 

 To my mind, the explanation of this pheno- 



