NON-SPORING BACILLI 291 



venously acted like the bovine type, killing with acute and 

 rapid tuberculosis ; in these cases, however, o-oi mgr. never 

 killed within three months, thus easily distinguishing the 

 bacilli from those taken as the standard. Hence this dose 

 is the best to use intravenously. 



Effects on chimpanzee and monkey in producing acute 

 tuberculosis, are similar to those produced by like doses of 

 the bovine tubercle bacillus. 



In guinea-pigs, it produces acute tuberculosis, but dura- 

 tion of life is longer than with the same dose of bovine 

 tubercle bacilli. 



In the goat, pig, and cat, great resistance is found, only 

 slight retrogressive lesions being produced. 



In the dog, the effects are similar to the bovine tubercle 

 bacillus, that is, there is great resistance to subcutaneous 

 injection, but large doses given intravenously or intra- 

 peritoneally cause generalized tuberculosis and death. 



In the fowl, the effects are the same as those produced 

 by the bovine tubercle bacillus. 



In a horse, subcutaneous injection of 50 mgr. produced 

 only local disease. 



The human tubercle bacillus has not shown any alteration 

 in cultural characters on prolonged cultivation. 



Resume. The human tubercle bacillus is distinguished 

 from the bovine tubercle bacillus by (1) Its more ready 

 growth on artificial media ; and (2) The results of inocula- 

 tion into rabbits, calves, cats, pigs, and goats. They 

 are alike in that they readily produce tuberculosis in 

 chimpanzees, monkeys, and guinea-pigs, and in that 

 the lesions produced in these animals are the same in 

 distribution and structure. 



3. Avian tubercle bacillus. The avian tubercle bacillus 

 forms a slimy, whitish growth, easily emulsified (difference 

 from human and bovine). It grows badly on serum, but 

 especially well on glycerinated media. Inoculation into 

 animals produces effects markedly contrasting with those 

 given by bovine and human tubercle bacilli. 



Fowls are very susceptible to intravenous, intramuscular, 

 and subcutaneous inoculation of the avian tubercle bacilli, 

 and also to feeding. In the former modes, the lesions are 

 in the spleen and liver, and frequently in the lungs, cervical 



