NON-SPORING BACILLI 297 



birds, in every one the virus found was of the avian type. 



In tuberculosis in pigs, the avian virus was found on 

 6 occasions in the submaxillary lymphatic glands ; in 

 5 alone, and in I case in association with the bovine virus. 



(Query. Is this due to special exposure of the pig to the 

 farmyard dust, and to its high body temperature ?) 



Behaviour of the Bacilli and their Fate in the 

 Tissues of Inoculated Animals. From a number of 

 experiments detailed, the Reporters conclude that after 

 subcutaneous inoculation of human and bovine viruses, 

 rapid and abundant distribution of bacilli over the body 

 takes place, provided the dose is large and the tissue condi- 

 tions of the animal such as to allow the inoculation to take 

 full effect. This is essentially a mechanical dispersion by 

 the blood and lymph channels of a considerable proportion 

 of injected bacilli, and occurs speedily after their insertion. 

 The resulting acute tuberculosis is at first in strong contrast 

 to the similar but more slowly developing generalized 

 disease induced by smaller experimental doses, or such as 

 occurs most commonly in nature. This more slowly 

 developing form is due to a dispersion of bacilli, but not 

 necessarily those primarily invading the animal ; more pro- 

 bably their progeny, which have been able to get through 

 the barriers and into the blood-stream. 



Feeding Experiments. In two pigs fed with large 

 doses of bovine virus, the bacilli were demonstrated (by 

 inoculation of guinea-pigs) in the submaxillary and mes- 

 enteric glands and lungs in seven and thirteen days after 

 ingestion, but not in the other organs. In seven pigs fed 

 with human virus, in from two to twelve days after 

 ingestion the same distribution was proved in two ; in 

 the other five the virus was found in the glands alone. 

 In a goat, eight days after ingestion of human bacilli, 

 they were found in the submaxillary glands, mesenteric 

 glands, and lung. In a cat fed with the same bacilli, 

 in nine days they were found in the submaxillary 

 and mesenteric glands, lung, liver, and spleen. Three 

 rhesus monkeys, each fed with 50 mgr. of human tubercle 

 bacilli, were killed ; 1 in two days, showed no bacilli in 

 the glands or internal organs; 1 in four days, showed 

 bacilli in the mesenteric glands, liver, spleen, and lungs 



