146 IMPORTANT VARIETIES OF FISSION-FUNGI. 



pneumonia, pleuritis, pericarditis, endocarditis, peritonitis, 

 otitis, meningitis, conjunctivitis, and ulcus serpens corneae. 

 More rarely as the cause of nephritis and perinephritis, 

 metritis, pyosalpinx, strumitis, parotitis, amygdalitis, 

 arthritis, 1 osteomyelitis, 'periostitis, abscesses, and general 

 sepsis. It may also cause erysipelas (Schurmayer, C. B. 

 xxin, 183). In many of these diseases the organism is 

 found not only locally, but also in the blood. Very often 

 other exciters of inflammation accompany and aid the 

 Strept. lanceolatus, which is always more difficult to cul- 

 tivate, so that if ordinary agar is employed for cultures, 

 staphylococci, etc., may alone be observed. Therefore 

 ascites-agar and similar media are to be preferred. The 

 Strept. lanceolatus escapes from the diseased person in the 

 milk and urine. 



Regarding the participation of the Strept. lanceolatus in cerebro- 

 spinal meningitis, see under Strept. intracellularis, page 148. 



Marchoux (A. P. xiu, 193) repeatedly found in soldiers, as a sequel 

 to pneumonia, a tendency to sleep ( ' ' Schlafsucht, ' ' maladie du som- 

 meil), and upon section there were changes in the cerebrospinal mem- 

 branes with the Strept. lanceolatus present. 



Experimental Observations Concerning Patho- 

 genic Effects. 2 (a) In animals : Of animals, the rabbit 

 and mouse are especially susceptible, the rat less so, and 

 guinea-pigs, sheep, dogs, and birds almost not at all. 



The mouse dies in from twelve to twenty-four hours after subcutan- 

 eous infection of septicemia; spleen enlarged, eyelids glued together. 

 In the blood are large numbers of diplococci. In mice pneumonia 

 also can be produced by inhalation. Likewise in rabbits septicemia 

 with fever and swelling of the spleen follows subcutaneous and more 

 rapidly intravenous inoculation with strongly virulent cultures; death 

 follows in forty-eight, twenty-four, twelve,' or even five hours. At- 

 tenuated cultures cause, according to the point of inoculation, pneu- 

 monia, pleuritis, peritonitis, etc. Honl especially recommends for 



1 Here also belongs the excitant of chronic deforming inflamma- 

 tion of joints, described by v. Dungern and Schneider (Munch, med. 

 Wochenschr., 1898, No. 43, 1369). 



2 The virulence is exceedingly variable and in the usual cultures it 

 is rapidly lost. For the preservation of the virulence of the Strept. 

 lanceolatus during about two months it was recommended, for ex- 

 ample, by Bordoni-Ufrrediizzi to dry upon glass the blood of rabbits 

 which the infection had killed. Foa places such blood for twenty -four 

 hours in the incubator, and then preserves it in the cold. 



