ACTION OF ANTIPYRETIC ANALGESICS 331 



order to ascertain whether these drugs produced a synergistic ef- 

 fect or not, the following combinations were also studied: ace- 

 tanilid and salol, phenacetin and salol, acetanilid and phenacetin, 

 aspirin and salol, and antipyrin and aspirin. The doses 

 of the drugs never exceeded those employed by conservative 

 therapeutists. 



SUMMARY OF EXPERIMENTS 



Owing to the expense of publication, it is impossible in this 

 paper to report in tabular form all the data obtained in the pres- 

 ent investigation. An analysis of the results obtained will there- 

 fore be only given, and a few tables illustrating the method of 

 carrying on the experiments. Tables 1, 2, and 3 exemplify three 

 of the experiments which have been performed. As will be seen, 

 upon examining them, they indicate the drug and the dose em- 

 ployed, the reaction time readings before the administration of 

 the drug, and several series of readings after the drug had been 

 taken. In each case the mean reading (M.), the mean variation 

 (m.v.), and in case of a complex reaction the number of errors, 

 committed are indicated. Furthermore, after the administra- 

 tion of the drug, the relative change in the mean readings and the 

 relative change in the mean variations have been also computed 

 and expressed in terms of percentages of the normal. In table 

 4, an attempt was made to summarize the results of all the ex- 

 periments. In this table the drugs used and their dosage are 

 indicated and the most striking or maximal effect of the drugs is 

 expressed in terms of percent of the normal reading. Further- 

 more, the time at which that effect was noticed is indicated and 

 in the case of the mathematical problems the run of errors is 

 expressed. 



