334 



D. I. MACHT, S. ISAACS AND J. GKEENBERG 



Isaacs; July 27, 1917, 



TABLE 3 



at 2.58 p.m.; antipyrin600 mgm. 



ANALYSIS 



A careful study and analysis of all the data obtained has led 

 the authors to the following conclusions. The results obtained 

 with antipyretics are quite different from those found after mor- 

 phin or opium. No primary stage of stimulation or shortened 

 reaction time was noted after administration of antipyretics, ex- 

 cept possibly after small doses of quinin. It was found that in 

 all cases the ordinary doses of antipyretics produced either very 

 little effect on the reaction time, or if affecting it at all, they al- 

 ways impaired it as indicated by the prolongation of the mean 

 readings, by the increase in the mean variations of readings, or 

 by both. The most powerful or depressant drug in this respect 

 was found to be pyramidon. This is not entirely surprising inas- 

 much as pyramidon in the author's (M.) experience and in the 

 experience of many physicians is one of the most efficient anal- 



