BOVINE TUBERCULOSIS. 205 



animals to virulent bacilli. But his experiments lack suffi- 

 cient confirmation to warrant their repetition in man. 



Both "TR" and "TO" are preserved in 20 per cent, 

 glycerin. 



Temporary benefit has followed the use of TR in lupus. 



Some striking results have accrued from the use of TR as 

 a therapeutic measure; and it is regarded by some as of equal 

 importance with hygiene and diet, with which it should 

 invariably be combined. Koch says that tuberculin is of 

 great value as a therapeutic agent in early, uncomplicated 

 cases. In more advanced cases it is necessary to wait until 

 the temperature becomes normal. The treatment should be 

 extended over considerable periods, with intervals of from 

 three to four months, until the injections no longer give any 

 reaction. The consensus of opinion seems to be that the 

 various sera used in the treatment of tuberculosis are of value 

 only in incipient cases and when used in conjunction with 

 other measures. They are all powerless to remove dead tissue 

 or newly formed tubercular tissue. 



Fisch immunized a horse with TR and then used its serum, 

 which he called antiphthisin. He has used this serum in the 

 treatment of tuberculosis, and, if his reports are reliable, the 

 results have been good in each case. Klebs used antiphth- 

 isin, but failed to get beneficial results. Antiphthisin is 

 really a very dilute tuberculin. 



Klebs advocated the use of another product of the tubercle 

 bacillus, known as tuberculocidin, which in the hands of some 

 clinicians has yielded remarkably good results. 



Maragliano's antitubercle serum is obtained from horses 

 immunized to tuberculosis with old or attenuated cultures 

 grown in glycerin-bouillon. The clinical results obtained 

 with these sera have been so uncertain that it is impossible to 

 make any definite statement as to their efficiency or utility. 



Bovine Tuberculosis. 



Tuberculosis in cattle is of special interest, because the 

 animal is one of the sources, and an important one, of our 

 food-supply. 



