APPENDIX III. 195 



Experiment 22. Two guinea-pigs, the hair and 

 nails of which showed no lithium, were given each 

 three grains of chloride of lithium. 



In the first, in two hours no lithium was in the 

 hair. In four hours lithium was in the hair of the 

 belly, but scarcely perceptible in the hair of the 

 head. In twenty-four hours it was very distinct in 

 the hair of the belly and the head, and in the nails. 

 For five days it was detected in each drop of the 

 urine. Ten days afterwards the urine showed 

 lithium very distinctly ; only after thirty-two days 

 was lithium absent from a few drops of the urine. 

 The thirty-third day after the dose the animal was 

 killed. No lithium was found in the bile, liver, 

 blood, lens, kidneys, spleen, or other parts, by 

 simply taking a small piece of the organ on a red- 

 hot wire. The evaporated aqueous extract of the 

 two lenses showed no trace of lithium ; when, how- 

 ever, the two kidneys were incinerated, the ash 

 treated with sulphuric acid, the resulting sulphates 

 exhausted with absolute alcohol and the alcoholic 

 extract evaporated to dryness, lithium was easily 

 detected in the residue. A portion of the liver, 

 treated in the same manner, also yielded lithium. 



The second guinea-pig gave traces of lithium in 

 the urine when one-eighth of an ounce was evapo- 

 rated and treated with sulphuric acid and alcohol, 

 thirty-nine days after the lithium was taken. 



It follows from these experiments on the rate of 

 passage of lithium into and out of the body, that 



With three grains of chloride of lithium, a young 

 guinea-pig in half an hour had lithium in the watery 



