352 



ON THE TOXICITY OF 



mately as follows : cocaine, I'O ; alypine, 0*9 ; holocaine, 0*6 ; 

 stovaine, O55 ; tropacocaine, 0*5 ; /3-eucaine, 0*4 ; nirvanine 

 and novocaine, 0*3. These numbers differ somewhat from 

 those given by Le Brocq, but considering the different methods 

 employed there is considerable agreement in the results. To 

 a large extent the differences, with the possible exception of 

 nirvanine, can be explained by differences in the rapidity of 

 absorption after hypodermic administration, which was the 

 method he employed. 



Two illustrative protocols of experiments are given. It is 

 only necessary to remark that the effect of alypine and cocaine 

 shown in the first experiment is less than that obtained in 

 any other experiment with the concentrations mentioned. 



RABBIT : 1850 grammes : Ether : Blood-pressure from Right 

 Common Carotid Artery: Injection into Right Anterior Facial 

 Vein : Respiration taken by means of a Phrenograph. 



