426 



NA TURE 



[Februakv 28, 1895 



Table III. 



Germany, Austria, Holland :- 

 Ko5>el (up to May 



1S94) 

 Kossel (March 15- 

 Drcember i, 



1894) 



Bokai 



Heubner... 



KaU 



'Aronson . . 



Korte 



Ranke 

 •Weibgen . 



Borger ... 



Knntzen 



Hager 



Moller 



Sonnenbur); 

 'Bacnisky (quoteil 

 by Virchow) .. 

 •Hahn 



Wiederhofer 



Schiller 



Strahltnann 



Rumpf .. 



blumcnfeld 



Heim 



Orandinger 



Monli 



Unlerholzner 

 Ganghofner 

 Olhcr observci.i 



Berlin 



Buda-Pesth 

 Berlin 



!," &c. 



Munich 



Berlin 



Greifswald 



Oscher leben 



Magdeburg 

 Berlin 



Vienna 

 Trieste 



Hamburg 

 .\ustria 

 Vienna 



Prague 



54 230 



117 >3 



35 5 



96 37 



128 17 



255 

 121 



'9 

 65 

 30 

 25 

 25 

 76 

 107 



303 



205 



100 



252 

 32 none 



100 ,, 

 26 



50 2 

 27 6 

 27 II 

 25 I 



3- 8 

 no, 14 



39 4 



49 

 24 

 45 



France, Italy, Belgium, Switzerland. 

 Roux, Martin, ai d 



Paris 



Chaillou 

 Moizard ... 

 Lebrelon... 



Rabot 



Mya 



M assei 

 Charon . . 



Seitz 



America :— 

 Whit- 



Muehlcck 



Welch ... 



Catlin 



Great Britain 



Cases reported in 

 the I.aiuel and 

 liriliih MeJi<al 



y I'll) nal 



Washbourn,ijoo<l- 

 all, and Card 



Lyons 



Florence 



Naples 



Belgium 



Constance 



448:109 



23' 34 

 242 28 



47 

 17 



16 



2 

 none 



'3l 4 



271 I 



New York 321 8 



riiiladelphia 

 Baltimore 



123 22 



'4 



17 



u = - 



2.2-3 



14 2 



385 

 13-2 

 I2-I 



33' 



21 o 



280 



6-6 



12 



4 



39-6 



20 6 



'32 

 24 

 24 



■7-8 

 00 

 00 

 80 

 40 



222 

 407 



4 

 2S-8 

 12 7 



10-2 



24 5 

 14.7 

 IIS 



34" 

 II 7 



00 

 307 



37 



25 'o 



, 34 7 



53S 

 62-5 

 38 9 

 32-5-41 

 53-8 

 49 2 

 40 o 

 20 



55-6 

 27 '6 



478 

 40 o 

 526 

 438 



120 



380 

 525 



66 6 

 49 



517 

 50 o ' 



50 o 



I 427 



( Two not 

 I ' Heated 



( died 



Average 



for 



London 



23'3 



Average 



for 

 Hospital 

 194 388 



It ii ohjecled, however, ihat general statistics of this kind are 

 of comparatively little vahic unless the age of the patient 

 irtaied is given. In order to determine the foundation upon 

 which this certainly very Icgilimale objection is based, I have 



* Thtre it piMl>aI.lv ftimc over)ap|nng, e»r>ccially in ihc Rerlin rietlrc.t. 

 ItiU fftCt must l>c ukcn into account in rlcalina ^s-ilh this tabic a« a whole. 



NO. 1322, VOL. si] 



taken four series of cases as reported, and have placed them 

 >ide by side. The percentages of deaths at certain ages in the 

 London Asylums Boaid hospitals before the serum treatment 

 are given in Table IV., the percentages of deaihs of four 

 observers who have used the serum, in Tables V. and VI. 



Table IV. — Showing the Mortality at Various Ages Jrom 



Diphtheria admitted into the Metropolitan Asylums 



Roarifs Hospitals in the years 1888-93. 



I'a^ts 



.idmttttd. 



Died. 



Mortality per 

 cent. 



L'nder 1 



1 to 2 



2 to 3 . 



3104 • 

 4 to 5 . 



Totals under 5 .. 



S to 10.. 

 10 10 \t,.. 



2971 



2462 



SS5 



1597 



705 



93 



53 8 



2S 6 

 10 ; 



Table V. 

 Skouiin« Mortality from Diphtheria r.t various Ages. 



I None of these were more than 13 years of age. 

 Taiii.k VI. 

 Baginsiy (ijiioted by Virehoxv). 



Wiihouc serum treatment. 



With serum treatment. 



Tieated. Died. Per cent.] Treated. Died. IPcrLcnt. 



o-2yeais.. 



2-4 .. • 



4-6 ,. . 



6-8 „ . 



8-10 ,, 



10-12 ,, . 

 12-14 .. 



34 

 S2 

 81 

 46 



30 

 18 



303 



40 



23s 

 195 



8 6 

 10 9 

 100 



00 



It isvery impiirlant, however, lhat the period of the disease at 

 which the treatment 'is commenced should be taken into account, 

 for, as already indicated, experience has taught that I lie later 

 the stages of the disease at which this serum is injected, Ihc 

 stronger must be the dose given. It is necessary, therefore, to 

 separate the cases in which the treatment is commenced at an 

 early period from those in which it is commenced only when 

 the poison has had time to disorganise the tissues, and to rentier 

 them iiicnpable o( rending to the antitoxic serum. 



