DEGENERATIONS AND INFILTRATIONS. 



267 



are formed at the expense of the cytoplasm, or, at any rate, the 

 cytoplasm disappears as they accumulate. 



If the change be only moderate in degree, it is possible for the 

 cell to return to its normal condition. The granules then disap- 

 pear, the cell recovers its original size, and there is no trace of the 

 morbid condition left. But the degeneration may be too extensive 

 to parmit of recovery. The cell then suifers disintegration ; the 

 granules become more abundant, the normal cytoplasm disappears, 



FIG. 245. 



*A ^M&Z&tftmZggZ 







Parcnchymatous nephritis, a, cross-section of a convoluted tubule of the kidney, the lin- 

 ing epithelium of which is the seat of albuminoid degeneration. The cells are swollen 

 and their bodies filled with abnormally coarse granules. The cells to the left are so far 

 disintegrated that the nuclei have lost most of their chromatin. Such cells cannot 

 recover. The cells to the right are less profoundly altered and their nuclei retain suf- 

 ficient chromatin to stain slightly. These cells might, perhaps, recover. Other con- 

 voluted tubules, similarly affected, are represented in oblique section. &, tubule with 

 low, unaffected epithelium, the nuclei of which stain deeply ; c, round-cell infiltration 

 of the interstitial tissue in the neighborhood of a Malpighian body, the edge of which is 

 just above the line c. Section stained with haematoxylin and eosin. 



and the nucleus falls into fragments (" karyolysis "), the whole cell 

 being reduced to a granular debris exhibiting no evidence of organ- 

 ization (Fig. 245). 



