1901] MICROSCOPICAL JOURNAL bi 
fibres, more and less affected parts of the nerve occur ir- 
regularly, often a less affected part being peripherally sit- 
uated to a part much more markedly degenerated. This 
fact has been stated by many observers, and examination 
of nerves by serial or nearly serial sections demonstrates 
the truth of this statement. 
The explanation may, I think, be sought in the second 
and third divisions of this paper to which I now refer 
briefly. 
(2) The Changes in the Blood-vessels.—These are: pro- 
liferation with enlargement of nuclei of the endothelial 
cells of the intima, as also nuclear proliferation in the me- 
dia and adventitia in the smaller arteries and capillaries, 
and to a much less extent in the smaller veins. 
The nuclei of the intima almost block the lumen of the 
smaller capillaries and all the smaller vessels in the nerve, 
and those in the muscles are similarly affected. These 
changes are well marked in peripheral neuritis, and are 
also found near the end of the central portion of a divided 
nerve, but are not nearly so definite in the peripheral end 
of a divided nerve. 
.3) Haudations into the Funicult,éc.—These are typical 
of toxic neuritis. They are well seen round the vessels, 
and especially those showing the nuclear changes. These 
exudations may also be seen round the blood-vessels of 
the peri- and epi-neurium and also the muscles. 
The nature of the exudation varies :—It is generally 
_apparently lymph witha varying number of leucocytes 
and lymphoid cells and sometimes red blood-corpuscles. 
The amount of the exudation varies greatly in differ- 
ent cases, and when they have been in existence for some 
time, young connective tissue cells may be seen replacing 
_the exudation, and of necessity resulting in incomplete 
recovery of function of the nerves so affected. Exudations 
almost certainly point to an inflammatory process as dis- 
tinct from simple degeneration. They are absent in the 
