102 THE AMERICAN MONTHLY [Apr 
The Germ of Cancer a Protozoan, a Single Cell. 
DR. HARVEY R. GAYLORD, BUFFALO, N. Y. 
We succeeded in cultivating, with comparative regu- 
larity, directly from cancer, from fluids which were in 
contact with cancer and from experimental animals these: 
organisms,the protozoa. We are prepared to state that all 
the organs, including the blood, taken from all regions in 
all cases dying of cancer, including sarcoma and epithe- 
lioma, contain large numbers of organisms. We have 
likewise observed in all cases of carcinoma and sarcoma 
thus far examined that the organisms, especially the 
younger forms, can be detected in the peripheral blood.. 
The quarter-grown forms of the organism of cancer con- 
form very closely in appearance with the ameboid bodies 
found in the blood by Pfeiffer and Reed after vaccination 
and in cases of small-pox. The questiom of the appear- 
ance of these organisms and the utilization of this fact as 
a means of diagnosis already forms the subject of a piece 
of research in our laboratory. 
Fourteen guinea pigs inoculated in the peritoneum with 
peritoneal fluid containing the organism gave an average 
length of life of 58 days; 4 inoculated in the peritoneum 
with cancer mush gave an average length of life of 57 
days ; 11 inoculated in the peritoneum with dried can- 
cerous lymph nodes, gave average length of life of 45 
4-11 days; 6 guinea pigs inoculated with peritoneal fluid 
and lymph nodes from animals which were infected in the 
above manner, gave an average length of life of 29 days 
—a little more than half the length of time for the ani- 
mal inoculated directly from man. 
This unquestionably shows the increased virulence of 
the organisms after passing through an animal. Weare 
continuing these experiments in modified form and shall 
report on them later. 
The average length of life for rabbits inoculated in va- 
