1901] MICROSCOPICAL J OURNAL. 103 
rious regions with the different forms of material used 
shows the greater resistance of this animal to infection. 
In our most recent experiments we have succeeded by 
growing the organism in a collodion sac in the peritoneal 
cavity of a rabbit, in so increasing the virulence of the 
organism that a healthy rabbit inoculated in the ear-vein 
died of general hematogenous infection from the organ- 
ism after a period of 15 days. 
It will be seen from these experiments that animals are 
readily infected when inoculated with carcinomatous ma- 
terial as well as pure cultures of the organism. The per- 
itoneal fluid used in all of these inoculations was bac- 
teriologically sterile and consisted essentially of a pure 
culture of the organism. A guinea pig and a rabbit which 
were inoculated with filtered serum from which the or- 
ganism had been removed, gave a respective length of 
life of 304 daysand 164 days. The organs of these ani- 
mals were free from parasites. 
The microscopical pathological findings in these cases 
were generally uniform. All the animals were greatly 
emaciated and presented, on opening the abdominal cav- 
ity, collapsed intestines, reddened peritoneum, enlarged 
peritoneal lymph nodes and a moderate amount of clear 
straw-colored fluid. The lungs were dark red in color, 
collapsed, heart containing but a small amount of blood, 
spleen enlarged and reddened, liver in many cases hyper- 
emic, and the kidneys generally injected. | 
In almost all cases, a fresh examination was made of 
the peritoneal fluid, the organs, and the blood; and when- 
ever made, large numbers of the parasites could be readi- 
ly detected, as already described.—American Journal of 
Medical Sciences, 
LATE.—Owing to a sudden and unexpected removal of 
our office, our work was disturbed and thrown behind in 
a troublesome manner but we are now catching up. 
