1901] MICROSCOPICAL JOURNAL. 141 
cardiac palpation, venous murmurs, some vertigo and tin- 
nitis, . 
The blood shows a most extraordinary and continually 
diminishing number of red cells, until the number may 
amount to only 143,000 to the cubic millimeter. In addi- 
tion the following points of great diagnostic importance 
are to be noted. First the individua) red cell is richer 
than normal in Haemoglobin; second, many are larger | 
than normal; third, the red corpuscles are deformed, some 
being ovoid, others irregular; fourth, there are present mi- 
crocytes or small cells; fifth, there are nucleated red cells, 
and, sixth, we may find megalocytes and megaloblasts 
which have a plain staining nucleus. The megaloblasts 
are termed corpuscles of Erlich, since he claims that they 
are Pathognomonic of pernicious anaemia. Anaemia, de- 
pending upon lack of Haemoglobin in the corpuscles rather 
than a decrease in their actual number, is seen most typi- 
cally in that condition termed Chlorosis. In this disease 
the corpuscular diminution is so slight that it may be to- 
tally ignored, but decrease in haemoglobin 1s very great. 
In connection with anaemia, I may speak of Leukaemia 
which means a marked increase in white cells, more par- 
ticularly the large mono-nuclear leucocytes, Pseudo-leu- 
kaemia or Hodgkins’ disease must be differentiated from 
true leukaemia, by the blood examination, it being stated 
that in this malady there is usually but a slight decrease 
in red cells and no other marked changes. 
The parasites of the blood occupy a vast field of study 
and are held accountable for the different fevers such as 
malaria, Tertian fever, Quartan fever and the so-called 
Aestivo-Autumnal fever. These parasites consist for a 
great part of the malarial germ of Laveran or the ‘‘Hae- 
matozoon Malariae,” and the “Filaria Sanguinis Homi- 
nis.” No more important addition to the study of dis- 
ease from a diagnostic standpoint has been made than the 
discovery of the presence of a parasite in the blood of 
