76 THE FEEBLY INHIBITED. 



Fi generation. If two persons who are simplex in the excitation factor 

 mate, we have the possible zygotic combinations in generation F 2 : 

 E2, Ee, and e 2 , of which the middle term will be as frequent as the first 

 and last together. Similarly, where a pure cheerful (C) and a depressed 

 (c) strain are mated, in the F 2 generation, C 2 , Cc, and c 2 combinations 

 will be found. If, finally, the mating be made between the Ee hybrids 

 and the Cc hybrids, we may get in a hybridized population no less than 

 9 combinations. These are listed in table A, which gives the zygotic 

 formula and with each a coefficient indicating roughly its relative 

 frequency, also a term which indicates the extremes of fluctuations of 

 mood of the person with the zygotic formula. One notes that, in 

 table A, it is assumed that there is typically a difference in the mood of 

 a person with two doses or only one dose of a determiner ; that two doses 

 of the E factor produce the choleric temperament, while only one dose 

 results in the nervous temperament; that two doses of the C factor 

 result in a normal, cheerful state, while if only one dose is present the 

 individual has a tendency to appear phlegmatic, and if C is wholly 

 absent, to appear melancholic. This difference in the expression of a 

 trait according as it depends on a duplex or simplex condition of the 

 determiner has been repeatedly noticed and is perhaps the general 

 rule. Yet all students of genetics are aware that in some cases the 

 traits arising from the simplex and the duplex conditions of the deter- 

 miners are indistinguishable, while in some other cases in the simplex 

 condition the trait may even fail to arise. These experimentally 

 observed facts have to be taken into account in comparing observed 

 behavior with probable zygotic constitution. 



Table A. — Zygotic formula of descendants of a mixture of excited and depressed strains. 



1. E2C2, choleric-normal. 



2. E2CC, choleric-phlegmatic. 



1. E2C2, choleric-depressed (melancholic). 



2. EeC2, nervous-normal. 



4. EeCc, nervous-normal (phlegmatic). 

 2. Eec2, nervous-depressed (melancholic). 



1. e2C2, normal. 



2. e2Cc, normal-depressed (phlegmatic). 

 1. e2C2, normal-depressed (melancholic). 



It is assumed, also, that the mixed or alternating states are due to 

 the concurrence of the presence of the excited and the absence of the 

 cheerful factors. It seems probable that, as experience shows, these 

 two states should not occur simultaneously, but should alternate. How- 

 ever, as psychiatrists know, the separation in time of these opposing 

 traits varies greatly, and not a few cases are known where the elated 

 and depressed states seem to appear in an intimate mixture. This 

 mixed condition is fully described, for example, by Stransky (191 1, 

 PP- 57~65). It appears in transition from the elated to the depressed 

 phase, but also wholly independent of such transition. The mixture 

 may be a very intimate, strictly simultaneous one, i. e., at the same 



