HYDROPHOBIA 163 



in no wise impaired his qualities as an experi- 

 menter. 



On the 10th of December, 1880, Pasteur, be- 

 ing informed by Dr. Lannelongue that he had 

 under treatment, at Trousseau a five-year-old 

 child who had been bitten by a mad dog, went 

 to obtain a specimen of his saliva. In the saliva 

 he discovered a microbe, which was not that of 

 hydrophobia, and which, when injected into 

 rabbits, caused their death within two days of 

 a different disease. Nevertheless, the saliva 

 contained the microbes of hydrophobia, but 

 they lost all their virulence within twenty-four 

 hours. Since rabies chiefly affects the nerve 

 centres, Pasteur inoculated rabbits and dogs 

 with the cranial marrow of rabid dogs. The 

 subjects inoculated developed hydrophobia 

 after a greater or less lapse of time, and the ex- 

 periments became difficult to follow and to con- 

 trol. In order to hasten the period of inocula- 

 tion, Pasteur conceived the idea of injecting the 

 matter containing the germs directly into the 

 dogs' skulls; but the idea of trepanning, neces- 



