HYDROPHOBIA 165 



and curiously exploring the premises, he ex- 

 hibited the keenest satisfaction and began to 

 lavish terms of endearment upon it. He felt 

 an infinite gratitude towards this particular dog 

 for having stood the trepanning so well, and 

 thus having put an end to all his scruples in 

 regard to future trepanning." l 



The experiment succeeded, and the period of 

 inoculation was reduced to twenty days, and it 

 was demonstrated that the principal seat of the 

 malady was in the nervous centres. To the first 

 results, which were of a theoretic character, 

 Pasteur became ambitious to add others of a 

 practical nature. Was it possible to render 

 dogs immune to hydrophobia after they had 

 been bitten, as he had rendered cattle and 

 sheep immune to anthrax? And could this im- 

 munity be extended to man? 



The problem was quite complex, for he did 

 not know the microbe of hydrophobia, which 

 had barely been detected by Dr. Roux, in the 



*L'Oeuvre Medicate de Pasteur, by Dr. Roux. Agenda 

 du Chimiste, 1896. 



