310 BOARD OF AGRICULTURE. [Pub. Doc. 



of the lip, a vesicle of the size of a cherry, distended with clear 

 fluid. This was ruptured by the animal on the day of its appear- 

 ance. No shnilar vesicles were observed in calves Nos. 2 and 3. 



These five calves ate well and were apparently thriving up to a 

 period of not more than twenty-four hours preceding their death. 

 It was noticed in some of the calves at this time that the mouth 

 felt slimy when the fingers were introduced for feeding. There 

 was no " slobbering" at any time. 



Twelve hours before death the animals were less active. Three 

 of the five were off their feed, and could only be roused up with 

 considerable difficulty. Followiug this the calves were unable to 

 stand. There was labored respiration for several hours before 

 death, and the animals became progressively weaker and finally 

 insensible. In each case death took place in about twelve hours 

 after the animal showed marked symptoms, i.e., loss of appetite 

 or weakness. There was no marked diarrhoea. 



Pathological Findings. 



There was slight hypostatic congestion of the lungs in two 

 calves, and in one of these there was about 400 cc. of fluid in the 

 pleural cavity. This process in the lung may have possibly been 

 produced by the passage into the lungs of medicine, administered 

 while the calf was comatose. 



The spleens were not enlarged, and appeared pale when sec- 

 tioned. The intestines were examined in all cases, and no lesions 

 found. 



The tongues were examined in all cases. In three calves, Nos. 

 1, 4 and 5, tliere were opaque patches on the upper surface of the 

 tongue, varying from 5 mm. to 3 cm. in diameter. The epithelium 

 here was soft, slightly swollen, and scraped off leaving a rough 

 but not a raw surface. These lesions were much more prominent 

 during life. In no case did these lesions appear vesicular, or con- 

 tain fluid. Microscopically, the lesions were found to be limited 

 chiefly to the epithelium, which had become necrotic over a sharply 

 limited area. The necrosis had extended through all the layers in 

 certain portions of the lesion. The cells were separated by a 

 fibrino-purulent exudate. The feet were examined, and there were 

 no vesicles present. 



In summary of the above experiments, it is to be observed that 

 all five calves presented a similarity of symptoms very suggestive 

 of a single disease. The date of death bears no relation to the 

 date of purchase. 



Calf No. 1 died four days after being vaccinated, and calves 

 Nos. 2 and 3 died five days after vaccination. 



