No. 4.] KKPORT OF CATTLK BUREAU. 311 



Calf No. 4 died three days after being placed where the others 

 had died, but had been in the stable bcdow for several days. 



Calf No. 5 died five days after introduction into the place occu- 

 pied by the first three calves. 



Inasmuch as the disease v, inch was killing these calves presented 

 features not ordinarily met with in vaccinia, and especially on 

 account of the peculiar lesions on the tongue suggesting foot and 

 mouth disease, the cases were reported to Dr. Austin Peters. 



The only features suggestive of foot and mouth disease were a 

 few inconsi)icuous tongue lesions and its seeming infectiousness. 

 Even tills infectiousness was doubtful, as the feeding of the calves 

 on a patent meal was more or less experimental. What made the 

 presence of foot and mouth disease seem still more improbable 

 was the failure of the four cows kept in the stable below to con- 

 tract the disease. During the entire experiments these cows were 

 fed each day from the buckets which were used in feeding the 

 calves. As no disease had appeared among the cows, the presence 

 of foot and mouth disease seemed improbable. 



However, on August 21, twelve days after the death of the last 

 calf, one of the cows refused food, and was observed " slobber- 

 ing." Examination of the mouth showed a ragged ulcer, 4 cm. 

 long, situated on the upper gum. In tr3aug to pull out tongue a 

 large triangular flap was torn from its tip, and the mucous mem- 

 brane seemed soft and mushy. Seen later in the day, there 

 appeared several elevated areas of mucous membrane on the dor- 

 sum of the tongue. Several shallow erosions were present about 

 the edges of the lips. Later on, vesicles developed on the feet. 

 The symptoms seemed characteristic of foot and mouth disease, 

 and the barn was immediately placed under quarantine. On the 

 day following symptoms appeared in the other animals. They 

 were all shot by the United States inspectors August 23. 



Part II. — The Experimental Inoculations carried on at 



THE Newcomb Estate. 



On account of association of vaccination inoculations with the out- 

 break of a disease characterized by vesicles of the mouth and feet, 

 it was considered important to investigate the matter at length. 



Several cows and calves were obtained by the United States 

 Bureau of Animal Industry, and kept in an isolated barn on the 

 Newcomb estate. Three calves were vaccinated on August 28 on 

 various parts of the body, including the nose and the edge of the 

 lower lip. The same virus was employed as was used in the vac- 

 cinations on July 31. The lesions developed in the usual manner, 

 except that on the fourth day a blister-like vesicle developed on. 



