29 



for at least twenty-four hours. During this time but small quan- 

 tities of food or water should be allowed, and all treatment that 

 would tend to cause excitement should be carefully avoided. 

 After a period of six hours has elapsed, following the injection of 

 the tuberculin, the temperature should be accurately taken at 

 intervals of two or two and one-half hours for twenty-four hours, 

 counting from the time the injection was made. 



What it does. 



The value of tuberculin as a diagnostic of tuberculosis in cattle 

 depends upon the fact discovered by Dr. Koch in his employment 

 of it as a cure for tuberculosis in persons ; that, when injected into 

 the body of a tuberculous patient, its use is followed by the devel- 

 opment of febrile symptoms, the most constant and noticeable of 

 which was a rise of the internal temperature. When employed in 

 a similar manner upon one not a subject of the disease, no marked 

 alterations of the normal functions occurred. 



As an illustration, the following tables are introduced to show 

 what might be expected in case of the use of tuberculin upon two 

 cows, one of which is healthy, the other tuberculous : — 



Healthy Coiv. 

 8 P.M., normal tempei'ature, 101.4° F. 



8.30 p M., tested with 2..') cubic centimeters 10 per cent tuberculin solu- 

 tion. 



2.30 A.M., . . . temperature, 101.2°. 



4.30 A.M., " 101.1°. 



6.30 A.M. " 101°. 



8.30 A.M., « 101°. 



11.00 A.M., " 101.2°. 



1.30 P.M , " 101.2°. 



4.00 P.M., " 102°. 



7.00 P.M « 101.3°. 



Tuberciilo2is Cow. 

 8 P.M., normal temperature, 100^ F. 



8.30 P.M., tested with 2.o cubic centimeters 10 per cent tuberculin solu- 

 tion . . 

 2.30 A.M temperature, 100.2°. 



4.30 A.M , 

 6..S0 A.M , 

 8. .30 A.M., 



11.00 A.M., 



1.30 P.M., 

 4.00 P.M., 

 7.00 P.M., 



101.2°. 



103°. 



104°. 



104.4'\ 



100.1°. 



105.2°. 



104.4°. 



