310 LEPROSY 



so numerous are they that the granulation tissue in sections, 

 properly stained as above, presents quite a red colour under a 

 low power of the microscope (Plate II., Fig. 8). The bacilli 

 occur for the most part within the protoplasm of the round 

 cells of the granulation tissue, and are often so numerous that 

 the structure of the cells is quite obscured (Fig. 90). They 

 are often arranged in bundles which contain several bacilli 



FIG. 91. High-power view of portion of leprous nodule, showing 

 the arrangement of the bacilli within the cells of the granulation tissue. 



Paraffin section ; stained with carbol-fuchsin and methylene-blue. 

 x 1100. 



lying parallel to one another, though the bundles lie in various 

 directions (Fig. 91 and Plate II., Fig. 9). The appearance thus 

 presented by the cells filled with bacilli is very characteristic. 

 Bacilli are also found free in the lymphatic spaces, but the greater 

 number are undoubtedly contained within the cells. They are 

 also found in spindle-shaped connective-tissue cells, in endothelial 

 cells, and in the walls of blood vessels. They are for the most 

 part confined to the connective tissue, but a few may be 

 seen in the hair follicles and glands of the skin. Occasionally 

 one or two may be found in the surface epithelium, where they 



