542 



PATHOGENIC FUNGI 



and it is followed by a succession of usually small granulomata, 

 whose distribution indicates a lymphatic spread. There is little 

 tendency to spontaneous cure. Apart from the skin, cases have 

 been recorded of lesions in the pharynx, larynx, muscle, bone, 

 and synovial membrane, and in animals (dogs, rats) generalised 

 infections of the serous cavities and solid organs have been 

 observed. The lesions are of a diffuse granulomatous character, 

 and at first consist of young connective-tissue elements and 



*L-4~" 





FIG. 169. Edge of living colony of Sporotrichon beurmanni on agar 

 hanging- drop, five days at 22 C. x 200. 



plasma cells with little leucocytic exudation. Later, many 

 fibroblasts develop, embedded in a fibrinous-like exudate. Diffuse 

 degeneration and necrosis occur and also leucocytic emigration 

 with the formation of abscesses, at first of microscopic size. When 

 the skin is involved, ulceration results. In certain cases abscess 

 formation is more marked. 



Direct examination of the pus may reveal the presence of oval, 

 highly refractile spores, 3-4 /*, long and T6-3 /x, broad, and 

 these may be demonstrated both free and in the granulomatous 

 cells, in films and sections stained by ordinary aniline dyes ; they 



