610 SMALLPOX AND VACCINATION 



insusceptible, the cornea may still in the monkey be sensitive 

 (this last fact is said not to be true for the rabbit). Again, 

 intraperitoneal infection with lymph is said not to be followed 

 by cutaneous immunity. Such facts have led some to suppose 

 that smallpox is essentially a disease of the cutaneous tissues. 

 In it we would have another example of local infection such as 

 is found in tubercular leprosy, lupus, and certain other skin 

 infections. Prowazek strongly holds that in cutaneous vaccinal 

 infection there is never a distribution of the virus throughout 

 the organs ; but this result has been disputed by other workers. 

 He also states that when the virus is injected intraperitoneally 

 it is soon taken up by leucocytes and is not absorbed into the 

 body fluids. 



