314 MANUAL OF BACTERIOLOGY. 



considerable time if kept from drying. The gonococcus is not 

 known to produce urethritis or conjunctivitis in any of the lower 

 animals. In the peritoneum it may cause suppurative in- 

 flammation in mice and guinea-pigs. Reproduction of the dis- 

 ease in man has been effected by experimental inoculation 

 with pure cultures. Besides being the cause of gonorrheal 

 urethritis and infection of the cervix uteri, the gonococcus has 

 been isolated from cases of vaginitis in little girls and from 

 gonorrheal conjunctivitis. It has been found to be the cause 

 of many cases of pyosalpinx, as well as of gonorrheal proc- 

 titis, naphritis, arthritis, myocarditis and endocarditis; these 

 conditions complicating gonorrhea may also be secondary or 

 mixed infections. 



Bacillus of Soft Chancre (of Ducrey). A small, oval 

 bacillus, usually occurring in chains. It stains with ordinary 

 aniline dyes, but not by Gram's method. It has been culti- 

 vated on human blood-agar (also rabbit blood-agar; the 

 medium deteriorates in a few weeks Davis). It is cultivated 

 with difficulty. It is found in the pus of soft chancre or chan- 

 croid, usually mixed with other organisms. It has been dem- 

 onstrated in sections of the ulcers. There seems to be un- 

 certainty with respect to its occurrence in buboes. Ducrey 

 was able to secure it in pure culture by successive inoculations 

 on the human skin. Although this bacillus has not yet been 

 sufficiently studied, there seems little doubt that it is the cause 

 of soft chancre.* 



Bacillus Pneumoniae (of Friedlander), or Bacillus mucosus 

 capsulatus.^ A short bacillus with rounded ends, sometimes 

 growing out to a greater length; sometimes occurring in pairs; 

 surrounded by a capsule which is seen only in preparations 

 made from the tissues of infected animals, and is not seen in 

 cultures. This bacillus is not motile. It does not form spores. 



*Davis. Journ. Medical Research. Vol. IX. 1903. 



fHoward. Philadelphia Medical Journal. February 19, 1908. Curry 

 Howard, Perkins. Journal Experimental Medicine. Vols. IV. and V. 



