PATHOGENIC BACTERIA. 



355 



rabbits, guinea-pigs, cats, field-mice and occasionally in other 

 animals. Guinea-pigs and rabbits are extremely susceptible. 

 A guinea-pig inoculated with tuberculous sputum (provided 

 it does not die of septicemia, due to the pyogenic micrococci 

 which are frequently present in sputum) will present a swelling 

 of the neighboring lymph-nodes in the course of two to four 

 weeks, and will die as a rule in from four to eight weeks, 

 although the time may be longer. 



Tuberculosis in cattle (German, Perlsuchf) is characterized by large, nodular 

 lesions, with a marked tendency to become fibrous, caseous and calcified. The 

 tubercle bacilli of cattle differ somewhat from those of human tuberculosis, as 

 was noted by Theobald Smith.* Whether or not men could be infected with 

 bovine tubercle bacilli has been a question that has been warmly debated in 

 recent years. There seems no longer room for doubt that such infection 

 does take place; also that cattle may be infected with human tubercle bacilli. 

 Bovine tubercle bacilli are more virulent for some animals, as rabbits, than 

 human tubercle bacilli.f 



The tubercle bacillus is present in all forms of tuberculosis, 

 in the sputum from the lungs of persons suffering with phthisis, 

 in all tissues affected with tuberculosis, as in the skin in lupus; 

 in tuberculous glands in all situations, in the cervical glands 

 in scrofula, in the mesenteric glands in intestinal tuberculosis; 

 it is present also in the feces in intestinal tuberculosis, in the 

 urine in tuberculosis of the urinary apparatus. Wherever 

 there is a tuberculous lesion in any location in man or in the 

 lower animals, and in the excreta and in the secretions from 

 tuberculous organs the tubercle bacillus is to be found. Not 

 only in such locations but also in certain conditions where 

 there is no lesion. It has been found in the mouth, throat 

 and nose of persons who show no symptoms or signs of tuber- 

 culosis, but who associate intimately with tuberculous persons. 

 It is found in the glands of persons dying from other causes 



* Journal Experimental Medicine. Vol. III., p. 451- 



fTheobald Smith. Medical News. February 22, 1902. Various bulletins 

 from the Bureau of Animal Industry. Adami. Philadelphia Medical Journal. 

 February 22, 1902. Ravenel. University of Pennsylvania Medical Bulletin. 

 May, 1902. Lartigau. Journal Medical Research. Vol. VI. 1901. Wolbach 

 and" Ernst. Ibid. XII., p. 295. Theobald Smith. Ibid. XIII., p. 299. 



