[ 604 ] 



incubating in the animals about to be inoculated, as in such 

 cases the simultaneous method of inoculation should not be 

 employed, but serum alone injected in large quantities should 

 diarrhoea not yet have supervened. If this latter symptom 

 should have already made its appearance nothing can save 

 the affected animal. 



"Experiments in the Laboratory. The experiments 

 carried out with the above mentioned method in this 

 Laboratory prove that the animals which show temperature 

 reactions with fairly marked symptoms are immune for up- 

 wards of one year, and there is no reason to doubt that it 

 will last for a much longer time, if not for the life of the 

 animals. On the other hand, the animals showing no tem- 

 perature reaction or symptoms of the -disease, partly due to 

 the large doses of serum used, may wear off their immunity 

 earlier than those which reacted to the simultaneous method, 

 and this difficulty can be got over by re-inoculating those 

 animals, which have not reacted within a week or ten days 

 of the simultaneous injection, with a second dose of from i 

 to 10 c. c* of virulent blood. 



"Results in field inoculations. The inoculations carried 

 out by the serum manufactured at this Laboratory in 

 Bareilly, Aligarh, Bulandshahr, and Dehra districts gave 

 eminently successful results, and Mr. Holmes in his report 

 from Madras states : ' Out of 339 bullocks inoculated, nine 

 died, but these deaths were attributed to old age and debilita- 

 ted conditions, and to the fact that the animals were suffering 

 from rinderpest previous to inoculation. I do not consider 

 that any of the deaths occurred as a direct result of inocula- 

 tion. 1 think it is safe to say that, as a result of these 

 inoculations, rinderpest was at once checked and a heavy loss 

 averted among the cattle. ' 



"By referring to Table C of the Assistant to the 

 Inspector General, Civil Veterinary Departments Annual 

 report for the year 1899-1900, we find that out of 1,730 



