54 BACTERIOLOGY 



ing of affected animals, and proper disinfection of their 

 quarters. 



Bacillus Leprse (Bacillus of Leprosy). A non-motile 

 bacillus. Spores have not as yet been demonstrated. 

 Sources of infection have not yet been determined. 

 Lesions are thickening and nodules of granulation tissue 

 in the skin and peripheral nerves, though other tissues 

 and the internal organs may be affected. It is un- 

 certain whether the disease may be transmitted from 

 one person to another or not. 



Leprolin. This is a substance analogous to tuberculin, 

 and is prepared from cultures of lepra bacilli. It is 

 used as a diagnostic measure and has shown little or 

 no curative properties. 



Bacillus of Bubonic Plague. A facultative anaerobic, 

 non-motile, non-spore-forming bacillus, the cause of 

 bubonic plague. 



Source of Infection. Fleas carry the infection from 

 rats to man and other animals, particularly ground 

 squirrels. Direct infection from dust or air seldom if 

 ever occurs. Infection doubtless always occurs through 

 the skin by the bite of a flea or fly, usually the rat 

 flea. 



No local reaction occurs at the site of infection, but 

 inflammation of the neighboring lymphatic glands soon 

 follows. 



Three forms of the disease are recognized: bubonic, 

 distinguished by enlargement and suppuration of the 



