94 BACTERIOLOGY 



serum were certain protein-like bodies called globulins, 

 and that by a process of precipitation and nitration 

 these could be separated from the inert elements of the 

 serum, thus reducing the bulk of the dose to be injected 

 and removing some of the objectionable effects which 

 sometimes followed the injection of large doses of the 

 non-concentrated antitoxin, such as urticaria, rashes, 

 etc. 



Marketing Antitoxin. The antitoxin is finally placed 

 in specially devised containers, which are made in the 

 form of a syringe with needle attached, each container 

 holding from 500 to 5000 units of antitoxin. The con- 

 tainer is sterilized and packed in an aseptic package 

 which may be opened at the bedside and found ready 

 for instant use. 



Dosage and Administration. As an immunizing dose, 

 that is, such as will prevent one who has been exposed 

 to the disease from becoming infected, 500 to 1000 units 

 may be given, depending upon the age or size of the 

 individual. 



A curative dose should never be less than 3000 units, 

 and 5000 had better be given at the beginning of any 

 case if seen early. If the case be not seen until it is 

 well advanced, one should not temporize, but should 

 give 10,000 units at once, and repeat the dose in four to 

 five hours if decided improvement has not occurred. 



Large doses can do no harm, and it must be remem- 

 bered that the longer the disease has been in progress the 



