INFLAMMATION AND PROCESSES OF REPAIR 145 



corresponds histologically to an abscess, the outer wall 

 of which is missing. The base of the ulcer, being 

 composed of granulation tissue, corresponds to the 

 pyogenic membrane of an abscess. 



Sinus. A sinus is the tortuous track by which a deep- 

 seated abscess opens upon the surface. A sinus cannot 

 heal until the suppurating surface or cavity which it 

 drains ceases to suppurate. 



WOUND REPAIR REGENERATION 

 Healing by First Intention. When the lips of a clean 

 aseptic wound are brought in apposition, proliferative 

 connective-tissue cells join the apposing walls, prolifer- 

 ative epithelial cells close over the surface, and the 

 wound is said to have healed by first intention. 



Healing by Second Intention. Should the walls of 

 the wound not be brought into apposition, or be exposed 

 to irritants, or become infected, granulations spring up 

 on the apposing surfaces, filling up the intervening space. 

 This granulation tissue is gradually converted into 

 fibrous tissue, the old epithelial cells at the edges of 

 the wound proliferate and cover over the surface of 

 the new-formed fibrous tissue, and the wound is said 

 to have healed by granulation or second intention. 



PROGRESSIVE PROCESSES 



Hypertrophy. The term "hypertrophy" is used to 

 designate that pathologic condition in which a tissue or 

 10 



