402 BACILLI IN CHRONIC INFECTIOUS DISEASES. 



after the inoculation, the two layers of the tunica vaginalis testis 

 are found to be covered with a purulent exudate containing the 

 glanders bacillus and to be more or less adherent. Even as early 

 as the second day the tunica vaginalis is seen to be covered with 

 granulations. 



An attenuation of virulence occurs in cultures whicn have been 

 kept for some time, and inoculations with such cultures may give a 

 negative result ; or, when considerable quantities are injected, may 

 produce a fatal result at a later date than is usual when small 

 amounts of a recent culture are injected into susceptible animals. 



Kalning, Preusse, and Pearson have obtained from cultures of 

 the glanders bacillus a glycerin extract similar to the crude tubercu- 

 lin of Koch mallein. This, when injected into animals suffering 

 from glanders, gives rise to a considerable elevation of temperature, 

 and it has been proposed to use it as a means of diagnosis in cases of 

 suspected infection in animals in which the usual symptoms have not 

 yet manifested themselves. The value of the test has already been 

 demonstrated by the experiments of Heyne, Schilling, and others. 



57. BACILLUS OF LUSTGARTEN. 



Synonym. Syphilis bacillus. 



Found by Lustgarten. (1884) in syphilitic lesions and in secretions of 

 syphilitic ulcers, and believed by him to be the specific infectious agent in 

 this disease. No satisfactory experimental evidence that this is the case has 

 yet been obtained. 



Morphology. Straight or curved bacilli, which bear considerable resem- 



FIG. 126. FIG. 127. 



FIG. 126. Migrating cell containing syphilis bacilli. (Lustgarten. ) 

 FIG. 127 Pus from hard chancre containing syphilis bacilli (Lustgarten.) 



blance to tubercle bacilli, but differ from them in the staining reactions. 

 They are usually more or less curved, or bent at a sharp angle, or S- shaped ; 

 the ends often present slight knob-like swellings ; the length is from three 

 and one-half ft to four and one-half /<, and the diameter is from 25 to 0.3 //. 

 With a high power the contour is seen to be not quite regular, but wavy in 

 outline, and bright, shining spaces in the deeply stained roda may be ob- 

 served ; these, from two to four in a single rod, are believed by Lustgarten 



