BACILLI IN CHRONIC INFECTIOUS DISEASES. 



405 



In gelatin stick cultures the growth, resembles that of Friedlander's ba- 

 cillus i.e., a nail-like growth, consisting of densely crowded, opaque colonies 

 along the line of puncture, and a heaped-up, white, glistening mass upon the 

 surface, hemispherical in form and viscous in consistence. Upon gelatin 

 plates yellowish-white, spherical colonies are developed within two or three 

 days, which under the microscope are seen to be granular. Upon potato a 

 cream-like growth occurs along the line of inoculation, which is white or 

 yellowish-white in color, and in which gas bubbles may be developed. De- 

 velopment is most rapid at a temperature of 35 to 38, but also occurs at the 

 room temperature. 



Pathogenesis. The etiological relation of this bacillus to the disease with 

 which it is associated has not been established. It is pathogenic for mice 

 and for guinea-pigs, less so for rabbits ; in this regard, as in its morphology 

 and growth in various culture media, it bears a close resemblance to Fried- 

 lander's bacillus, which is also found not infrequently in the nasal secretions 

 of healthy persons and in those suffering from chronic nasal catarrh or ozaena. 



The principal points of difference, as pointed out by Baumgarten, are as 

 follows : The bacillus of rhinoscleroma is usually more decidedly rod-shaped 



FIG. 128. Bacillus of rhinoscleroma in lymphatic vessels of the superficial part of tumor. 

 X 1,200. (Cornil and Babes ) 



than Friedlander's bacillus, although both may be of so short an oval as to 

 resemble micrococci. The first-mentioned bacillus constantly presents the 

 appearance of being surrounded by a transparent capsule, even in the cul- 

 tures in artificial media, while Friedlander's bacillus in such media does not 

 usually present this appearance, unless as a result of special treatment. 

 Finally, the bacillus of rhinoscleroma may retain its color, in part at least, 

 when treated by Gram's method, while Friedlander's bacillus is completely 

 decolorized when placed in the iodine solution employed in this method. 



Notwithstanding these points of difference, Baumgarten is not entirely 

 satisfied that this bacillus is a distinct species, and several bacteriologists 

 have maintained that it is identical with the bacillus of Friedlander. 



59. BACILLUS OF KOUBASOFF. 



Obtained by Koubasoff (1889) from new growths in the stomach of a 

 person who died of cancer of the stomach. 



Morphology. Bacilli with round ends, or with one end pointed, two or 

 three times as long as the tubercle bacillus and three or four times as thick. 



Stains readily with the aniline colors. 



Biological Characters. A.n aerobic and facultative anaerobic, non- 

 liquefying, motile bacillus. Forms spores in the centre of the rods. Grows 

 in the usual culture media at the room temperature, more rapidly at 36 C. 



