THE INHERITANCE OF FAMILY TRAITS IG9 



persons; and it is lost in the product of marriage of an alkapto- 

 nuria and a normal person. 



b. Cystinuria and Cystin Infiltration are both family diseases 

 though so rare that the method of inheritance has not been 

 precisely determined. 



Fig. 149. — Pedigree of a family showing hematuria (red urine). AfTected 

 persons (black symbols) are descended from an affected parent, evidence that 

 hematuria is a positive trait. Guthrie. 



c. Hemattiria, or red urine, may also be a family char- 

 acteristic as the pedigree chart worked out by Guthrie shows 

 (Fig. 149). 



d. Urinary Calculi. — This is frequently hereditary. A ped- 

 igree recorded by Cluble (1872) illustrates this fact, though 

 it does not give sufficient data to determine the law of 

 inheritance. He says: — ''During the last four or five years 

 I have cut three of liis sons [i. e., of the Lowestoft fisherman] 

 at the respective ages of 2, 3, and 8. Two of the stones were 

 Hthic acid, one apparently lithate of ammonia. The father 

 and mother of the lads always have lithic acid sediment, often 

 gravel, deposited from urine. Their grandfather passed one 

 stone, their grandmother seven. A great uncle was cut for 

 stone. There are six uncles and four aunts who suffer from 

 fits of gravel or from gravelly or sedimentary lithic acid 

 deposits; and a cousin, an uncle's child, gets rid of urinary 

 calcuh." 



e. Gout. — The hereditary tendency to gout is generally 



