32 



0"iiKMl^AT10NS UK INFLAAIMATION. 



Tio. 5. — ^Purulent granulations from 

 the subcutaneous tissue of a rabbit round 

 about a ligature, a. Connective tissue 

 corpuscles, b. Enlargement of the cor- 

 puscles, with division of the nuclei c. 

 Division of the cells (granulations), d. 

 Development of the jjua corpviscleB. — 



(VlRCHOW.) ~ 



[mediate tissueT^whicli continually liquefies and becomes more 



and more scanty as the pro- 

 liferation of the cells extends. 

 It is held that tliis liquefaction 

 is of a chemical nature ; the 

 intermediate substance (which 

 'is of a glutinous nature) be- 

 comes converted ultimately into 

 an albuminous fluid, and is ren- 

 dered liquid. "VVe thus see that 

 pus is not derived from any 

 effusion, but that it is formed 

 by vital changes in the germs 

 of the tissue, and that, by a 

 slight modification of the same 

 process,- newlconnectiveXtissue is formed. The outmost layer 



of the intercellular tissue is 

 often long preserved, whilst 

 all its deeper parts are already 

 filled with pus corpuscles, 

 or are converted into an 

 abscess; at last the surface 

 'gives way, or, without giving 

 I way, is directly transformed 

 into a soft diffluent mass. — 

 (VlRCHOW ) 



The pus itself was for- 

 merly thought to have solvent 

 properties, and tliat by this 

 power it was enabled to find its way to the surface, but experi- 

 ments have proved this to be incorrect Bones have been 

 placed in cavities full of pus, and left there for weeks, and 

 when they were afterwards weighed, they have, if anything, 

 become heavier, through the absorption of fluid matters, but no 

 softening has been produced, except that caused by decomposi- 

 tion. How far the tissue is destroyed by solution chiefly de- 

 pends upon the question whether the substance that surrounds 

 the young cells becomes completely fluid. If it retains a cer- 

 tain degree of consistence, the process is confined to the pro- 

 duction of granulations, and these may as well proceed from a 



^zAim.K8 or CzulB. 

 "FlO. 6. — a, a. Young cells. . h and ci 

 Connecting tissue cells ; and d. Pus cell, 

 all derived from a. 



