GEKMS. 57 



Pilocarpine stimulates the same nerves and they pour 

 out large amounts of fluid. Chloroform weakens the 

 nerve supplying the heart, glonoin strengthens it. 



The poison generated in the system and which causes 

 typhoid fever and other diseases mentioned, does not 

 stimulate the nerves supplying the glands or tissues 

 which produce the white corpuscles, hence there is no 

 increase. These nerves are stimulated by other self- 

 generated poisons, and there is an increase. This ac- 

 counts for the disease Leucocythemia, already men- 

 tioned, in which there is an enormous increase in the 

 white corpuscles. 



The spleen and lymph glands of the body are the 

 structures which supply the white corpuscles, and in 

 Leucocythemia these are all enlarged showing over- 

 stimulation. The spleen may become so large as to 

 nearly fill the whole of the abdominal cavity. The 

 spleen enlarges more than other glands, because its 

 blood-supply is proportionately larger, and the blood- 

 vessels are not continued through the organ as through 

 other structures, but the circulation is continued 

 through openings that are channeled through the spleen 

 itself. This brings the irritating blood in direct con- 

 tact with the spleenic tissues. 



The liver is also much enlarged, because the veins 

 from the spleen empty directly into the liver. The 

 white corpuscles become so numerous that the blood 

 loses its red color and looks almost white. The pres- 

 sure of the spleen and liver interfere with the lung- 

 action and respiration is lessened. The pressure also 

 interferes with the heart-action and there is weakness 



