XL] BACILLUS: PATHOGENIC FORMS. 125 



Experiments by feeding and inoculation made on dogs and 

 cats, rabbits, guinea-pigs, and mice, with the ham that had 

 done the mischief in the Welbeck case produced positive 

 results. In all cases we found pneumonia and haemorrhage 

 in the liver, peritonitis in some, spleen enlarged in most. 

 The bacilli found in this ham were cultivated in the incubator 

 in white of egg, and after two days' cultivation four white 

 rats, and several guinea-pigs and white mice were inoculated, 

 and they became ill after twenty-four hours ; they were quiet, 

 did not feed well, and were more or less soporous. When 

 killed the spleen was found enlarged, and in the lungs were 

 found haemorrhage and hyperaemia, and in some cases 

 extensive pneumonia. 



Blood, pericardial exudation, and lung juice from the fatal 

 Nottingham case inoculated into ten animals (guinea-pigs 

 and white mice) produced fatal results in six, the other four 

 were killed : but in all there was severe pneumonia, in eight 

 out of the ten there was peritonitis, in four also pleuritis, and 

 in two in addition enlargement of the liver and spleen. Bacilli 

 were found in the blood and exudations of these animals. 

 On cultivating blood and lung juice from the above case a 

 crop of bacilli was produced, which on inoculation proved 

 very poisonous in the same way as in the previous cases. 1 



(e) Bacillus malaria. Klebs and Tommasi-Crudeli 2 de- 

 scribed a bacillus occurring in the soil of the Roman 

 Campagna, which they cultivated on gelatine. The rods 

 are about 0*002 to o'ooy mm. long; they grow in cultures 

 into long leptothrix filaments composed of short joints. The 

 rods form spores either in the centre or at their ends. They 

 grow well also in other media, e.g. albumen, urine, and glue. 



1 Compare also Huber, Archivf. klin. Med. xxv. 

 a Archiv f. exp. Path. vol. xi. 



